Applying solitary-molecule optical and AFM imaging and power-spectroscopy tactics, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate pursuits include things like:
1996, to start with mesoscopic charge density waves units; and to start with electrical measurements on just one steel nanocluster among nanoelectrodes
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Non-equilibrium folding of person DNA molecules recaptured as much as 1000 occasions inside a solid state nanopore
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Our investigation ranges with the biophysics of DNA to artificial cells and over and above. Remember to have a look below in the spectrum of our present projects.
‘At first we looked at Organic methods by using a Actual physical view and acted on The idea with the applications we knew. It took a couple of years ahead of we begun Operating far more on the massive Organic issues. I then started to get in touch with it nanobiology, a expression that didn't exist at enough time.
2011, to start with in vitro measurements of transportation across an individual biomimetic nuclear pore sophisticated; advancement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
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1). The existing–voltage curves showed sizeable modulations with gate voltage, even at area temperature, which was consistent with band bending in the ~0.six eV bandgap semiconducting nanotube. These knowledge also confirmed that the conductance can be modulated by six orders of magnitude by transforming the gate voltage. The outcomes of the function — a place-temperature transistor produced from one carbon nanotube molecule — were revealed in Mother nature in Could 1998.
[fourteen] In 2005 Dekker became involved with Netherlands-wide discussions about Clever Style, a motion that he has because Plainly distanced himself from. Dekker advocates that science and faith usually are not in opposition but is usually harmonized.
A lot of new phenomena had been discovered, and he and his exploration group recognized a leading situation On this field of investigation. Dekker and his study team discovered new physics of nanotubes together with explored the feasibility of molecular electronics. In 1998, they had been the main to construct a transistor dependant on an individual nanotube molecule.
For instance, we look at the nucleopore elaborate, a gateway involving the cell nucleus and also the cytoplasm. This is a really intricate program and therefore tricky https://www.ceesdekker.net to review within a mobile, so we use biomimetics. We reconstruct holes and afterwards insert personal elements with the nucleopore sophisticated to study transport by it at the single-molecule amount.’
Sound-condition nanopores have verified for being a incredibly adaptable probe for solitary-molecule Examination of DNA. I will describe some of our recent findings – precisely DNA knots – and our endeavours to extend the abilities of stable-condition nanopores even even more, while in the route of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.